PF3D7_1349700

Genome location: Pf3D7_13_v3:1,998,716..1,999,945(+)

Genome classification: Core

Function and Localization

Product Description: peptidase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.04	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1349700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.82 | MFS: 0.797 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDK2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110253

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	16	9	23
disruptive	1	16	17	25
missense	1	16	17	21

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	24	16	21
disruptive	6	35	32	60
missense	5	33	26	43

PlasmoDB Total SNPs: 46

Non-coding: 36 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 255 | Molecular Weight (kDa): 29.566

UniProt ID(s): Q8IDK2

PDB ID(s): None

Isoelectric Point: 8.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	PF13398	N/A
Superfamily	N/A	N/A