Product Description: GPN-loop GTPase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.5.- (Acting on GTP; involved in cellular and subcellular movement.)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0005524 | ATP binding |
| Function | GO:0003924 | GTPase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.29 | 0.85 |
| Trophozoite | expressed | 0.17 | 0.90 |
| Schizont | not expressed | 0.04 | 0.97 |
| Gametocyte | possibly expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1349800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -3.171 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1362600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDK1
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.26) with 5HCI (Global RMSD=2.02)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.5.- | Ex: heterotrimeric G-protein GTPase | GDPGTPITPNEMEDTANO3-PlexANH4ClppGppstatinCCG-977Rap1Gap... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102080
Most Similar Human Ortholog: F8W1F4
TM-align score: 0.93 | RMSD: 1.31
Seq Identity: 0.38 | Length: 157 / 439
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000111231 | GPN-loop GTPase 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 22 | 10 | 32 |
| disruptive | 1 | 27 | 25 | 56 |
| missense | 1 | 27 | 25 | 51 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 46 | 25 | 32 |
| disruptive | 3 | 86 | 41 | 104 |
| missense | 2 | 74 | 36 | 67 |
PlasmoDB Total SNPs: 72
Non-coding: 45 | Synonymous: 21 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 439 | Molecular Weight (kDa): 52.158
UniProt ID(s): Q8IDK1
PDB ID(s): None
Isoelectric Point: 4.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004130 | GPN-loop GTPase |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR030228 | GPN-loop GTPase 3 |
| PFam | PF03029 | GPN-loop GTPase |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
No associated publications