PF3D7_1349900

Genome location: Pf3D7_13_v3:2,002,379..2,002,989(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.12	0.92
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.18	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1349900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.924 | MFS: -2.171 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1362700)

Relative Growth Rate: 0.13 ± 0.05
Confidence: 7.39

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K985

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532596

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	14	7	14
disruptive	4	25	13	35
missense	3	18	11	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	26	10	10
disruptive	7	53	27	42
missense	4	38	22	31

PlasmoDB Total SNPs: 32

Non-coding: 12 | Synonymous: 15 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 186 | Molecular Weight (kDa): 22.402

UniProt ID(s): A0A5K1K985

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A