PF3D7_1350000

Genome location: Pf3D7_13_v3:2,003,004..2,005,374(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.07	0.95
Schizont	no data	0.02	0.99
Gametocyte	no data	1.07	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1350000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.106 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9A3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	14	10	20
disruptive	8	33	17	57
missense	8	32	17	54

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	28	14	17
disruptive	11	75	30	62
missense	11	66	28	47

PlasmoDB Total SNPs: 175

Non-coding: 157 | Synonymous: 7 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 267 | Molecular Weight (kDa): 32.076

UniProt ID(s): A0A5K1K9A3

PDB ID(s): None

Isoelectric Point: 8.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A