PF3D7_1350200 (SNRPE)

Genome location: Pf3D7_13_v3:2,009,378..2,010,603(-)

Genome classification: Core

Function and Localization

Product Description: small nuclear ribonucleoprotein E, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005685	U1 snRNP
Component	GO:0005686	U2 snRNP
Component	GO:0005687	U4 snRNP
Component	GO:0046540	U4/U6 x U5 tri-snRNP complex
Component	GO:0005682	U5 snRNP
Component	GO:0071011	precatalytic spliceosome
Component	GO:0005732	sno(s)RNA-containing ribonucleoprotein complex
Process	GO:0006396	RNA processing
Process	GO:0000375	RNA splicing, via transesterification reactions
Process	GO:0000398	mRNA splicing, via spliceosome
Process	GO:0000387	spliceosomal snRNP assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.62	0.71
Trophozoite	not expressed	0.84	0.54
Schizont	not expressed	0.15	0.90
Gametocyte	not expressed	0.51	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1350200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.929 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDJ7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102613

Most Similar Human Ortholog: A6NHK2

TM-align score: 0.97 | RMSD: 0.45

Seq Identity: 0.61 | Length: 52 / 93

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000182004	small nuclear ribonucleoprotein polypeptide E

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	1	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	1	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 82

Non-coding: 73 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 93 | Molecular Weight (kDa): 10.927

UniProt ID(s): Q8IDJ7

PDB ID(s): None

Isoelectric Point: 9.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001163	LSM domain, eukaryotic/archaea-type
InterPro	IPR010920	LSM domain superfamily
InterPro	IPR027078	Small nuclear ribonucleoprotein E
PFam	PF01423	LSM domain, eukaryotic/archaea-type
Superfamily	SSF50182	LSM domain superfamily