PF3D7_1350300

Genome location: Pf3D7_13_v3:2,010,870..2,012,401(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	1.02	0.56
Trophozoite	expressed	0.80	0.57
Schizont	possibly expressed	0.14	0.92
Gametocyte	expressed	0.71	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1350300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.853 | MFS: -2.368 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8F9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130920

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	12	3	21
disruptive	11	48	46	87
missense	5	39	40	66

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	24	19	22
disruptive	32	145	64	139
missense	13	102	53	79

PlasmoDB Total SNPs: 117

Non-coding: 68 | Synonymous: 24 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 305 | Molecular Weight (kDa): 36.438

UniProt ID(s): A0A5K1K8F9

PDB ID(s): None

Isoelectric Point: 10.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027973	Protein of unknown function DUF4602
PFam	PF15375	Protein of unknown function DUF4602
Superfamily	N/A	N/A