PF3D7_1350500

Genome location: Pf3D7_13_v3:2,014,953..2,019,472(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.73	0.66
Trophozoite	expressed	0.71	0.60
Schizont	expressed	0.87	0.53
Gametocyte	expressed	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1350500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.145 | MFS: -2.888 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1363300)

Relative Growth Rate: 0.19 ± 0.16
Confidence: 5.04

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8S2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533246

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	62	41	82
disruptive	48	227	105	219
missense	37	196	91	186

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	133	54	101
disruptive	106	430	178	372
missense	74	354	138	233

PlasmoDB Total SNPs: 284

Non-coding: 131 | Synonymous: 86 | Nonsynonymous: 67 | Stop Codon: 0

Protein Information

Protein Length: 1144 | Molecular Weight (kDa): 133.581

UniProt ID(s): A0A5K1K8S2

PDB ID(s): None

Isoelectric Point: 7.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A