PF3D7_1350600

Genome location: Pf3D7_13_v3:2,021,350..2,022,307(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MNRIYLFVFLFVCCFVSSVIG

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.06	0.96
Gametocyte	no data	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1350600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.267 | MFS: -3.216 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K900

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533659

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	15	4	18
disruptive	11	17	7	22
missense	11	16	7	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	23	12	10
disruptive	22	34	21	59
missense	18	23	18	46

PlasmoDB Total SNPs: 22

Non-coding: 7 | Synonymous: 2 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 261 | Molecular Weight (kDa): 31.35

UniProt ID(s): A0A5K1K900

PDB ID(s): None

Isoelectric Point: 10.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A