PF3D7_1350800

Genome location: Pf3D7_13_v3:2,025,366..2,026,106(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.07	0.95
Schizont	not expressed	0.13	0.92
Gametocyte	expressed	0.71	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1350800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.608 | MFS: -2.866 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8M5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532463

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	16	11	16
disruptive	5	23	16	48
missense	5	23	16	44

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	35	16	18
disruptive	8	63	41	77
missense	6	52	36	45

PlasmoDB Total SNPs: 9

Non-coding: 1 | Synonymous: 3 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 246 | Molecular Weight (kDa): 29.674

UniProt ID(s): A0A5K1K8M5

PDB ID(s): None

Isoelectric Point: 9.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A