PF3D7_1351000

Genome location: Pf3D7_13_v3:2,032,016..2,040,395(+)

Genome classification: Core

Function and Localization

Product Description: phosphatidylinositol transfer protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Function	GO:0005548	phospholipid transporter activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.73	0.66
Trophozoite	expressed	0.64	0.65
Schizont	possibly expressed	0.65	0.64
Gametocyte	not expressed	0.83	0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1351000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.852 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDI9

"Best" AlphaFill ligand hit: PCW ((z,z)-4-hydroxy-n,n,n-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium-4-oxide, Local RMSD=1.19) with 2A1L (Global RMSD=3.00)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103092

Most Similar Human Ortholog: I3L471

TM-align score: 0.92 | RMSD: 1.15

Seq Identity: 0.38 | Length: 97 / 1860

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000174238	phosphatidylinositol transfer protein alpha
ENSG00000180957	phosphatidylinositol transfer protein beta

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	144	67	138
disruptive	81	340	219	454
missense	55	285	187	363

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	53	250	84	131
disruptive	148	759	316	615
missense	96	602	241	426

PlasmoDB Total SNPs: 357

Non-coding: 159 | Synonymous: 110 | Nonsynonymous: 88 | Stop Codon: 0

Protein Information

Protein Length: 1860 | Molecular Weight (kDa): 221.105

UniProt ID(s): Q25906, Q8IDI9

PDB ID(s): None

Isoelectric Point: 6.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001666	Phosphatidylinositol transfer protein
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR037239	Oxysterol-binding protein superfamily
PFam	PF00169	Pleckstrin homology domain
PFam	PF02121	Phosphatidylinositol transfer protein
Superfamily	SSF144000	Oxysterol-binding protein superfamily
Superfamily	SSF50729
Superfamily	SSF55961