PF3D7_1351100

Genome location: Pf3D7_13_v3:2,039,975..2,042,372(-)

Genome classification: Core

Function and Localization

Product Description: CXXC motif containing zinc binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0008270	zinc ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.28	0.86
Trophozoite	expressed	0.42	0.74
Schizont	expressed	0.05	0.96
Gametocyte	possibly expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1351100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.154 | MFS: -3.307 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDI8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102587

Most Similar Human Ortholog: Q9NWV4

TM-align score: 0.89 | RMSD: 1.92

Seq Identity: 0.26 | Length: 155 / 156

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000162384	CXXC motif containing zinc binding protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	1
missense	0	0	0	0

PlasmoDB Total SNPs: 177

Non-coding: 168 | Synonymous: 5 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 156 | Molecular Weight (kDa): 18.691

UniProt ID(s): Q8IDI8

PDB ID(s): 1ZSO

Isoelectric Point: 4.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008584	CXXC motif containing zinc binding protein, eukaryotic
PFam	PF05907	CXXC motif containing zinc binding protein, eukaryotic
Superfamily	SSF141678	N/A