PF3D7_1351200

Genome location: Pf3D7_13_v3:2,042,430..2,048,269(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MNLLVICIYYLFFLNIEKNISC

# Transmembrane Domains: 1

EC Numbers: 3.2.1.23 (Beta-galactosidase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.18	0.91
Trophozoite	expressed	0.73	0.60
Schizont	possibly expressed	0.18	0.89
Gametocyte	not expressed	0.46	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1351200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.079 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9F9

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.2.1.23	beta-galactosidase	BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532723

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	30	85	56	100
disruptive	96	237	118	279
missense	47	176	102	227

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	44	163	72	117
disruptive	168	461	217	427
missense	83	338	176	266

PlasmoDB Total SNPs: 259

Non-coding: 108 | Synonymous: 80 | Nonsynonymous: 71 | Stop Codon: 0

Protein Information

Protein Length: 1550 | Molecular Weight (kDa): 186.322

UniProt ID(s): A0A5K1K9F9

PDB ID(s): None

Isoelectric Point: 9.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001944	Glycoside hydrolase, family 35
InterPro	IPR017853	Glycoside hydrolase superfamily
InterPro	IPR031330	Glycoside hydrolase 35, catalytic domain
PFam	PF01301	Glycoside hydrolase 35, catalytic domain
Superfamily	SSF51445	Glycoside hydrolase superfamily