PF3D7_1351300

Genome location: Pf3D7_13_v3:2,048,381..2,049,656(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1351300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.152 | MFS: -2.616 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1364100)

Relative Growth Rate: 0.96 ± 0.14
Confidence: 5.25

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1369800)

Modification: Disrupted | RMgm-5273

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K904

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102477

Most Similar Human Ortholog: Q86TL2

TM-align score: 0.59 | RMSD: 2.98

Seq Identity: 0.23 | Length: 196 / 362

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000213533	STIM activating enhancer
ENSG00000248592	STIMATE-MUSTN1 readthrough

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	23	12	30
disruptive	17	84	54	95
missense	15	72	46	82

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	38	29	32
disruptive	32	186	66	122
missense	27	158	50	87

PlasmoDB Total SNPs: 57

Non-coding: 32 | Synonymous: 10 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 362 | Molecular Weight (kDa): 43.435

UniProt ID(s): A0A5K1K904

PDB ID(s): None

Isoelectric Point: 7.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022127	Store-operated calcium entry regulator STIMATE/YPL162C
PFam	PF12400	Store-operated calcium entry regulator STIMATE/YPL162C
Superfamily	N/A	N/A