About Gene List

PF3D7_1351400

Genome location: Pf3D7_13_v3:2,051,487..2,053,580(+)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal protein L17, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022625 cytosolic large ribosomal subunit
Component GO:0005634 nucleus
Function GO:0003735 structural constituent of ribosome
Process GO:0002181 cytoplasmic translation
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.08 0.53
Trophozoite expressed 1.34 0.38
Schizont expressed 0.24 0.84
Gametocyte expressed 0.60 0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1351400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.212 | MFS: -3.294 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1364200)

  • Relative Growth Rate: 0.06 ± 0.07
  • Confidence: 6.66

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDI5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100758

Most Similar Human Ortholog: A0A087WY81

TM-align score: 0.97 | RMSD: 0.67

Seq Identity: 0.57 | Length: 97 / 203

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000215472 RPL17-C18orf32 readthrough
ENSG00000265681 ribosomal protein L17

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 13 6 12
disruptive 1 8 7 10
missense 1 8 6 9

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 21 10 17
disruptive 1 28 11 40
missense 1 20 7 23

PlasmoDB Total SNPs: 141

Non-coding: 133 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 203 | Molecular Weight (kDa): 23.415

UniProt ID(s): Q8IDI5

PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD

Isoelectric Point: 11.56

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001063 Ribosomal protein L22/L17
InterPro IPR005721 Ribosomal protein L22/L17, eukaryotic/archaeal
InterPro IPR036394 Ribosomal protein L22/L17 superfamily
PFam PF00237 Ribosomal protein L22/L17
Superfamily SSF54843 Ribosomal protein L22/L17 superfamily

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
28288098 Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit proteinsynthesis. Wong W, Bai XC, ..., Baum J 10.1038/nmicrobiol.2017.31
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596