Product Description: glycerol kinase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.1.30 (Glycerol kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0005524 | ATP binding |
| Function | GO:0004370 | glycerol kinase activity |
| Function | GO:0016773 | phosphotransferase activity, alcohol group as acceptor |
| Process | GO:0006071 | glycerol metabolic process |
| Process | GO:0046167 | glycerol-3-phosphate biosynthetic process |
| Process | GO:0016310 | phosphorylation |
| Process | GO:0006641 | triglyceride metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.20 | 0.90 |
| Trophozoite | expressed | 0.10 | 0.94 |
| Schizont | expressed | 0.25 | 0.85 |
| Gametocyte | expressed | 1.56 | 0.52 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1351600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.682 | #Insertions: 4
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDI4
"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=0.30) with 6JAF (Global RMSD=1.73)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.1.30 | glycerol kinase | ATPADPAMPDTNBHgCl2CrATPNa2SO4ethanolglucoseEIIAMtlglycerol(NH4)2SO4... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100613
Most Similar Human Ortholog: Q14410
TM-align score: 0.94 | RMSD: 1.83
Seq Identity: 0.39 | Length: 494 / 501
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000196475 | glycerol kinase 2 |
| ENSG00000198814 | glycerol kinase |
| ENSG00000229894 | glycerol kinase 3 pseudogene |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 32 | 9 | 35 |
| disruptive | 1 | 21 | 14 | 37 |
| missense | 1 | 21 | 14 | 33 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 65 | 21 | 31 |
| disruptive | 6 | 60 | 29 | 87 |
| missense | 3 | 56 | 25 | 58 |
PlasmoDB Total SNPs: 64
Non-coding: 34 | Synonymous: 22 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 501 | Molecular Weight (kDa): 56.653
UniProt ID(s): Q8IDI4
Isoelectric Point: 6.19
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000577 | Carbohydrate kinase, FGGY |
| InterPro | IPR005999 | Glycerol kinase |
| InterPro | IPR018483 | Carbohydrate kinase, FGGY, conserved site |
| InterPro | IPR018484 | Carbohydrate kinase, FGGY, N-terminal |
| InterPro | IPR018485 | Carbohydrate kinase, FGGY, C-terminal |
| InterPro | IPR043129 | ATPase, nucleotide binding domain |
| PFam | PF00370 | Carbohydrate kinase, FGGY, N-terminal |
| PFam | PF02782 | Carbohydrate kinase, FGGY, C-terminal |
| Superfamily | SSF53067 | ATPase, nucleotide binding domain |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 19040641 | Structure and non-essential function of glycerol kinase in Plasmodium falciparumblood stages. | Schnick C, Polley SD, ..., Baker DA | 10.1111/j.1365-2958.2008.06544.x |
| 23954205 | Reduced glycerol incorporation into phospholipids contributes to impairedintra-erythrocytic growth of glycerol kinase knockout Plasmodium falciparumparasites. | Naidoo K, Coetzer TL | 10.1016/j.bbagen.2013.08.006 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |