About Gene List

PF3D7_1351700 (IMC1f)

Genome location: Pf3D7_13_v3:2,058,839..2,064,747(+)

Genome classification: Core

Function and Localization

Product Description: inner membrane complex protein 1f

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045178 basal part of cell
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.68 0.79
Trophozoite possibly expressed 0.10 0.94
Schizont expressed 1.54 0.46
Gametocyte not expressed 0.19 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1351700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.301 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1364400)

  • Relative Growth Rate: 0.89 ± 0.06
  • Confidence: 7.03

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1370200)

Modification: Tagged | RMgm-4491

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K988

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_201813

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 88 46 74
disruptive 65 218 121 238
missense 39 179 110 210

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 30 148 55 116
disruptive 113 398 195 349
missense 71 339 162 264

PlasmoDB Total SNPs: 270

Non-coding: 133 | Synonymous: 75 | Nonsynonymous: 60 | Stop Codon: 2

Protein Information

Protein Length: 1318 | Molecular Weight (kDa): 151.517

UniProt ID(s): A0A5K1K988

PDB ID(s): None

Isoelectric Point: 9.17

Protein Domain Annotations:

Source Family ID Description
InterPro IPR022086 Inner membrane complex protein
PFam PF12314 Inner membrane complex protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
18359944 Alveolins, a new family of cortical proteins that define the protist infrakingdomAlveolata. Gould SB, Tham WH, ..., Waller RF 10.1093/molbev/msn070
31097714 An essential contractile ring protein controls cell division in Plasmodiumfalciparum. Rudlaff RM, Kraemer S, Streva VA, Dvorin JD 10.1038/s41467-019-10214-z