PF3D7_1351800

Genome location: Pf3D7_13_v3:2,065,333..2,067,148(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKVLLYNILFVLYSICALC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	not expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1351800.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXH0

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.39) with 6JWW (Global RMSD=16.84)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533420

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	13	7	16
disruptive	19	45	17	50
missense	14	38	13	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	25	9	17
disruptive	27	101	40	96
missense	21	80	31	54

PlasmoDB Total SNPs: 86

Non-coding: 61 | Synonymous: 12 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 230 | Molecular Weight (kDa): 27.094

UniProt ID(s): A0A143ZVD1

PDB ID(s): None

Isoelectric Point: 5.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036249	Thioredoxin-like superfamily
PFam	N/A	N/A
Superfamily	SSF52833	Thioredoxin-like superfamily