PF3D7_1351900

Genome location: Pf3D7_13_v3:2,067,513..2,068,916(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.28	0.86
Trophozoite	expressed	0.40	0.76
Schizont	expressed	0.18	0.88
Gametocyte	expressed	0.50	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1351900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.828 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9A6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532450

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	16	14	25
disruptive	16	62	50	82
missense	6	51	46	67

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	37	15	30
disruptive	31	166	50	127
missense	13	137	42	77

PlasmoDB Total SNPs: 62

Non-coding: 14 | Synonymous: 36 | Nonsynonymous: 10 | Stop Codon: 2

Protein Information

Protein Length: 412 | Molecular Weight (kDa): 49.049

UniProt ID(s): A0A5K1K9A6

PDB ID(s): None

Isoelectric Point: 6.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018800	Proline-rich protein PRCC
PFam	PF10253	Proline-rich protein PRCC
Superfamily	N/A	N/A