About Gene List

PF3D7_1352000

Genome location: Pf3D7_13_v3:2,069,203..2,075,512(+)

Genome classification: Core

Function and Localization

Product Description: GTP-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.24 0.88
Trophozoite expressed 0.98 0.51
Schizont expressed 0.50 0.73
Gametocyte expressed 0.74 0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1352000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.77 | MFS: -3.03 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8H4

"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=0.49) with 5WBG (Global RMSD=14.30)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532631

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 89 42 113
disruptive 112 383 174 424
missense 63 288 138 332

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 25 169 83 137
disruptive 210 705 297 599
missense 120 517 221 400

PlasmoDB Total SNPs: 375

Non-coding: 35 | Synonymous: 171 | Nonsynonymous: 169 | Stop Codon: 0

Protein Information

Protein Length: 2006 | Molecular Weight (kDa): 240.019

UniProt ID(s): A0A5K1K8H4

PDB ID(s): None

Isoelectric Point: 5.85

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006073 GTP binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFam PF01926 GTP binding domain
Superfamily SSF52540 P-loop containing nucleoside triphosphate hydrolase

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895