Genome location: Pf3D7_13_v3:2,075,535..2,079,893(-)
Genome classification: Core
Product Description: ABC transporter B family member 6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 5
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016020 | membrane |
| Function | GO:0005524 | ATP binding |
| Function | GO:0042626 | ATPase-coupled transmembrane transporter activity |
| Process | GO:0055085 | transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.32 | 0.84 |
| Trophozoite | possibly expressed | 0.34 | 0.81 |
| Schizont | expressed | 0.62 | 0.69 |
| Gametocyte | not expressed | 0.41 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1352100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -2.87 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1364800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_1364800)
Modification: Disrupted | RMgm-4328
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDH9
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.04) with 6R72 (Global RMSD=2.63)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9NP58 | ATP-binding cassette sub-family B member 6 | Homo sapiens | OrthoDB | MLS001002340MLS002701786 |
Protein Length: 1049 | Molecular Weight (kDa): 123.663
UniProt ID(s): I6Q0F3, I6Q0Y6, I6Q0Y7, I6Q0Z1, I6Q2K4, I6Q2K8, I6Q2K9, I6Q2L2, I6Q2L4, I6Q415, I6Q5G8, I6Q5H0, Q8IDH9, S5Y677, S5Y681, S5ZEQ3
PDB ID(s): None
Isoelectric Point: 9.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003439 | ABC transporter-like |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR011527 | ABC transporter type 1, transmembrane domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
| InterPro | IPR039421 | Type I protein exporter |
| PFam | PF00005 | ABC transporter-like |
| PFam | PF00664 | ABC transporter type 1, transmembrane domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF90123 | ABC transporter type 1, transmembrane domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 58 | 44 | 95 |
| disruptive | 17 | 126 | 82 | 175 |
| missense | 11 | 112 | 73 | 157 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 126 | 67 | 86 |
| disruptive | 48 | 305 | 130 | 285 |
| missense | 33 | 247 | 103 | 186 |
PlasmoDB Total SNPs: 179
Non-coding: 96 | Synonymous: 52 | Nonsynonymous: 31 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 38145744 | Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5beta/B6and ABCB5beta/B9 | Gerard L, Duvivier L, ..., Gillet JP | 10.1016/j.jbc.2023.105594 |
| 38319451 | Cadmium transport by mammalian ATP-binding cassette transporters | Thevenod F, Lee WK | 10.1007/s10534-024-00582-5 |
| 37044150 | Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway topromote ferroptosis in multiple myeloma | Yin Z, Lv Y, ..., Liu S | 10.1016/j.freeradbiomed.2023.04.003 |