PF3D7_1352200 (UTP15)

Genome location: Pf3D7_13_v3:2,079,867..2,083,628(+)

Genome classification: Core

Function and Localization

Product Description: U3 small nucleolar RNA-associated protein 15, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.58	0.71
Trophozoite	expressed	0.22	0.87
Schizont	expressed	0.16	0.90
Gametocyte	expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1352200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.729 | MFS: -2.182 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8T1

"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.03) with 6Y7O (Global RMSD=2.52)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102263

Most Similar Human Ortholog: Q8TED0

TM-align score: 0.59 | RMSD: 2.63

Seq Identity: 0.18 | Length: 295 / 464

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000164338	UTP15 small subunit processome component

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	30	25	42
disruptive	12	40	35	80
missense	12	39	35	73

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	69	28	31
disruptive	20	105	65	134
missense	18	86	62	82

PlasmoDB Total SNPs: 208

Non-coding: 174 | Synonymous: 18 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 464 | Molecular Weight (kDa): 55.268

UniProt ID(s): A0A5K1K8T1

PDB ID(s): None

Isoelectric Point: 9.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
Superfamily	SSF50978	WD40-repeat-containing domain superfamily