About Gene List

PF3D7_1352400 (NUP176)

Genome location: Pf3D7_13_v3:2,087,113..2,092,848(+)

Genome classification: Core

Function and Localization

Product Description: nucleoporin NUP176, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0034399 nuclear periphery
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.50 0.77
Trophozoite expressed 1.16 0.43
Schizont expressed 0.59 0.69
Gametocyte possibly expressed 0.66 0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1352400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.991 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1365100)

Modification: Tagged | RMgm-5247

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K907

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=1.09) with 6JWW (Global RMSD=17.70)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533525

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 96 49 105
disruptive 45 145 107 240
missense 28 125 92 199

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 28 180 73 112
disruptive 86 377 179 481
missense 49 301 145 295

PlasmoDB Total SNPs: 163

Non-coding: 50 | Synonymous: 68 | Nonsynonymous: 44 | Stop Codon: 1

Protein Information

Protein Length: 1594 | Molecular Weight (kDa): 190.29

UniProt ID(s): A0A5K1K907

PDB ID(s): None

Isoelectric Point: 8.77

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
36040030 TurboID Identification of Evolutionarily Divergent Components of the Nuclear PoreComplex in the Malaria Model Plasmodium berghei. Ambekar SV, Beck JR, Mair GR 10.1128/mbio.01815-22