Product Description: thioredoxin-related protein, putative
SignalP Peptide: MAIFKKSIIIFLFFTFFNYCFS
# Transmembrane Domains: 2
EC Numbers: 5.3.4.1 (Protein disulfide-isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020020 | food vacuole |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003756 | protein disulfide isomerase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.33 | 0.85 |
| Trophozoite | expressed | 1.42 | 0.36 |
| Schizont | expressed | 0.96 | 0.56 |
| Gametocyte | expressed | 0.69 | 0.62 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1352500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.195 | MFS: -3.317 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDH5
"Best" AlphaFill ligand hit: 2CV (hega-10, Local RMSD=0.33) with 6H7L (Global RMSD=2.39)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.3.4.1 | protein disulfide-isomerase | NEM16F16LOC14AsO43-CCF642MA3 018MA3 019acroleinneomycinpeptidesgenisteinkanamycin... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q15084 | Protein disulfide-isomerase A6 | OrthoDB | CHEMBL4751979 |
Protein Length: 208 | Molecular Weight (kDa): 23.988
UniProt ID(s): Q8IDH5
PDB ID(s): None
Isoelectric Point: 9.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013766 | Thioredoxin domain |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF00085 | Thioredoxin domain |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 7 | 19 |
| disruptive | 1 | 10 | 2 | 16 |
| missense | 1 | 9 | 2 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 27 | 10 | 22 |
| disruptive | 1 | 27 | 15 | 44 |
| missense | 1 | 17 | 13 | 32 |
PlasmoDB Total SNPs: 107
Non-coding: 98 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |