PF3D7_1352600

Genome location: Pf3D7_13_v3:2,096,326..2,099,369(-)

Genome classification: Core

Function and Localization

Product Description: protein kinase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Function	GO:0009931	calcium-dependent protein serine/threonine kinase activity
Function	GO:0005516	calmodulin binding
Process	GO:0035556	intracellular signal transduction
Process	GO:0018105	peptidyl-serine phosphorylation
Process	GO:0046777	protein autophosphorylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.24	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1352600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.962 | MFS: -2.929 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5I3

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=1.31) with 3HX4 (Global RMSD=4.92)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533462

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	23	17	25
disruptive	3	50	22	55
missense	3	50	22	48

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	46	16	37
disruptive	9	98	42	110
missense	8	82	36	79

PlasmoDB Total SNPs: 133

Non-coding: 115 | Synonymous: 13 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 422 | Molecular Weight (kDa): 50.598

UniProt ID(s): C0H5I3

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000719	Protein kinase domain
InterPro	IPR011009	Protein kinase-like domain superfamily
InterPro	IPR011992	EF-hand domain pair
PFam	PF00069	Protein kinase domain
Superfamily	SSF47473	EF-hand domain pair
Superfamily	SSF56112	Protein kinase-like domain superfamily