Genome location: Pf3D7_13_v3:2,110,042..2,113,787(+)
Genome classification: Core
Product Description: vacuolar fusion protein MON1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Function | GO:0032266 | phosphatidylinositol-3-phosphate binding |
| Function | GO:0010314 | phosphatidylinositol-5-phosphate binding |
| Function | GO:0001786 | phosphatidylserine binding |
| Process | GO:0043547 | positive regulation of GTPase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.18 | 0.91 |
| Trophozoite | expressed | 0.57 | 0.67 |
| Schizont | expressed | 0.18 | 0.88 |
| Gametocyte | expressed | 0.46 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1352800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -3.008 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1365400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDH2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102023
Most Similar Human Ortholog: E7EW32
TM-align score: 0.76 | RMSD: 2.61
Seq Identity: 0.20 | Length: 358 / 884
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000103111 | MON1 homolog B, secretory trafficking associated |
| ENSG00000164077 | MON1 homolog A, secretory trafficking associated |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 24 | 17 | 39 |
| disruptive | 22 | 75 | 45 | 121 |
| missense | 14 | 61 | 40 | 102 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 56 | 28 | 61 |
| disruptive | 44 | 143 | 100 | 173 |
| missense | 28 | 122 | 81 | 123 |
PlasmoDB Total SNPs: 140
Non-coding: 80 | Synonymous: 39 | Nonsynonymous: 21 | Stop Codon: 0
Protein Length: 884 | Molecular Weight (kDa): 103.839
UniProt ID(s): Q8IDH2
PDB ID(s): None
Isoelectric Point: 4.57
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004353 | Vacuolar fusion protein Mon1 |
| InterPro | IPR043971 | FUZ/MON1/HPS1, second Longin domain |
| InterPro | IPR043972 | FUZ/MON1/HPS1, first Longin domain |
| PFam | PF19036 | FUZ/MON1/HPS1, first Longin domain |
| PFam | PF19037 | FUZ/MON1/HPS1, second Longin domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 28288121 | A genetic system to study Plasmodium falciparum protein function. | Birnbaum J, Flemming S, ..., Spielmann T | 10.1038/nmeth.4223 |