About Gene List

PF3D7_1352900

Genome location: Pf3D7_13_v3:2,113,577..2,116,771(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: MRVFWVVLCYLDTLVNI

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.51 0.43
Trophozoite possibly expressed 0.22 0.89
Schizont expressed 0.20 0.88
Gametocyte not expressed 0.13 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1352900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.983 | MFS: -2.343 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDH1

"Best" AlphaFill ligand hit: CTS (castanospermine, Local RMSD=2.46) with 2VL8 (Global RMSD=23.68)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533263

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 12 10 19
disruptive 66 33 16 65
missense 65 33 15 59

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 29 11 26
disruptive 80 76 33 102
missense 77 59 28 83

PlasmoDB Total SNPs: 133

Non-coding: 58 | Synonymous: 14 | Nonsynonymous: 61 | Stop Codon: 0

Protein Information

Protein Length: 582 | Molecular Weight (kDa): 68.929

UniProt ID(s): Q8IDH1

PDB ID(s): None

Isoelectric Point: 9.02

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
15591202 Targeting malaria virulence and remodeling proteins to the host erythrocyte. Marti M, Good RT, ..., Cowman AF 10.1126/science.1102452
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g