Genome location: Pf3D7_13_v3:2,129,062..2,131,680(+)
Genome classification: Core
Product Description: membrane associated histidine-rich protein 2
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.21 | 0.90 |
| Trophozoite | expressed | 0.03 | 0.99 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1353200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.91 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDG8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 153
Non-coding: 150 | Synonymous: 0 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 137 | Molecular Weight (kDa): 15.849
UniProt ID(s): Q8IDG8
PDB ID(s): None
Isoelectric Point: 7.34
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 20624222 | MAHRP2, an exported protein of Plasmodium falciparum, is an essential componentof Maurer's cleft tethers. | Pachlatko E, Rusch S, ..., Beck HP | 10.1111/j.1365-2958.2010.07278.x |
| 26803412 | A highly sensitive self assembled monolayer modified copper doped zinc oxidenanofiber interface for detection of Plasmodium falciparum histidine-richprotein-2: Targeted towards rapid, early diagnosis of malaria. | Brince Paul K, Kumar S, ..., Singh SG | 10.1016/j.bios.2016.01.036 |
| 27380525 | HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR forDetection of Malaria Infection during Pregnancy and at Delivery in Areas ofVaried Transmission: A Prospective Cohort Study in Burkina Faso and Uganda. | Kyabayinze DJ, Zongo I, ..., Bell D | 10.1371/journal.pone.0156954 |
| 28192523 | Bead-based immunoassay allows sub-picogram detection of histidine-rich protein 2from Plasmodium falciparum and estimates reliability of malaria rapid diagnostictests. | Rogier E, Plucinski M, ..., Barnwell J | 10.1371/journal.pone.0172139 |
| 28465622 | Sequence variation in Plasmodium falciparum Histidine Rich Proteins 2 and 3 inIndian isolates: Implications for Malaria Rapid Diagnostic Test Performance. | Kumar Bharti P, Singh Chandel H, ..., Singh N | 10.1038/s41598-017-01506-9 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 29376283 | [Analysis of polymorphism of Pfhrp2 gene in Plasmodium falciparum from falciparummalaria patients in Yunnan Province]. | Ying D, Ai-Ming S, ..., Hen-Lin Y | 10.16250/j.32.1374.2016113 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 30737461 | Plasmodium falciparum histidine-rich protein (PfHRP2 and 3) diversity in Westernand Coastal Kenya. | Nderu D, Kimani F, ..., Velavan TP | 10.1038/s41598-018-38175-1 |
| 31476617 | A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infectedErythrocytes. | Takano R, Kozuka-Hata H, ..., Kato K | 10.1016/j.isci.2019.07.035 |
| 31888663 | Genetic polymorphism of histidine rich protein 2 in Plasmodium falciparumisolates from different infection sources in Yunnan Province, China. | Dong Y, Liu S, ..., Xue J | 10.1186/s12936-019-3084-4 |
| 32184257 | Role of Plasmodium falciparum Protein G EXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum E MP1 Trafficking | McHugh E, Carmo OMS, ..., Dixon MWA | 10.1128/mBio.03320-19 |
| 33298142 | Disruption of Plasmodium falciparum histidine-rich protein 2 may affect haemmetabolism in the blood stage. | Yang Y, Tang T, ..., Chen Q | 10.1186/s13071-020-04460-0 |
| 35439987 | Low prevalence of Plasmodium falciparum parasites lacking pfhrp2/3 genes amongasymptomatic and symptomatic school-age children in Kinshasa, Democratic Republicof Congo. | Nundu SS, Arima H, ..., Yamamoto T | 10.1186/s12936-022-04153-2 |
| 23421990 | Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodiumfalciparum | McMillan PJ, Millet C, ..., Tilley L | 10.1111/cmi.12125 |
| 29673877 | The Plasmodium knowlesi MAHRP2 ortholog localizes to structures connecting SintonMulligan's clefts in the infected erythrocyte | Asare KK, Sakaguchi M, ..., Kaneko O | 10.1016/j.parint.2018.04.005 |
| 37000891 | Formation of ER-lumenal intermediates during export of Plasmodium proteinscontaining transmembrane-like hydrophobic sequences | Levray YS, Bana B, ..., Osborne AR | 10.1371/journal.ppat.1011281 |