About Gene List

PF3D7_1353300

Genome location: Pf3D7_13_v3:2,132,005..2,139,029(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.34 0.84
Trophozoite possibly expressed 1.38 0.36
Schizont expressed 1.03 0.48
Gametocyte expressed 1.24 0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1353300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.963 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDG7

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=1.26) with 6JWQ (Global RMSD=43.10)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533400

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 133 64 149
disruptive 72 391 191 446
missense 50 362 176 414

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 44 231 89 160
disruptive 142 787 318 584
missense 93 670 278 443

PlasmoDB Total SNPs: 285

Non-coding: 100 | Synonymous: 95 | Nonsynonymous: 90 | Stop Codon: 0

Protein Information

Protein Length: 2068 | Molecular Weight (kDa): 248.26

UniProt ID(s): Q8IDG7

PDB ID(s): None

Isoelectric Point: 8.54

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
17653272 Rapid identification of malaria vaccine candidates based on alpha-helical coiledcoil protein motif. Villard V, Agak GW, ..., Corradin G 10.1371/journal.pone.0000645
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895