PF3D7_1353400

Genome location: Pf3D7_13_v3:2,139,411..2,143,719(+)

Genome classification: Core

Function and Localization

Product Description: Ran-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.42	0.80
Trophozoite	expressed	0.64	0.64
Schizont	expressed	0.25	0.83
Gametocyte	possibly expressed	0.40	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1353400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.753 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDG6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156376

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	56	42	74
disruptive	40	197	122	246
missense	28	174	107	202

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	115	59	74
disruptive	71	464	197	352
missense	46	386	151	211

PlasmoDB Total SNPs: 184

Non-coding: 57 | Synonymous: 80 | Nonsynonymous: 47 | Stop Codon: 0

Protein Information

Protein Length: 1164 | Molecular Weight (kDa): 140.421

UniProt ID(s): Q8IDG6

PDB ID(s): None

Isoelectric Point: 6.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001876	Zinc finger, RanBP2-type
InterPro	IPR035979	RNA-binding domain superfamily
InterPro	IPR036443	Zinc finger, RanBP2-type superfamily
PFam	N/A	N/A
Superfamily	SSF54928	RNA-binding domain superfamily
Superfamily	SSF90209	Zinc finger, RanBP2-type superfamily