About Gene List

PF3D7_1353600 (ERD2)

Genome location: Pf3D7_13_v3:2,145,221..2,147,873(-)

Genome classification: Core

Function and Localization

Product Description: ER lumen protein retaining receptor

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005794 Golgi apparatus
Component GO:0005801 cis-Golgi network
Component GO:0005783 endoplasmic reticulum
Function GO:0046923 ER retention sequence binding
Function GO:0005046 KDEL sequence binding
Function GO:0038023 signaling receptor activity
Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Process GO:0006621 protein retention in ER lumen

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.08 0.96
Trophozoite expressed 0.19 0.87
Schizont expressed 0.24 0.83
Gametocyte expressed 0.08 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1353600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.972 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1130200)

  • Relative Growth Rate: 0.10 ± 0.30
  • Confidence: 3.81

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q76NM1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101087

Most Similar Human Ortholog: O43731

TM-align score: 0.97 | RMSD: 1.03

Seq Identity: 0.45 | Length: 214 / 221

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000100196 KDEL endoplasmic reticulum protein retention receptor 3
ENSG00000136240 KDEL endoplasmic reticulum protein retention receptor 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 165

Non-coding: 153 | Synonymous: 12 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 221 | Molecular Weight (kDa): 26.447

UniProt ID(s): P33948, Q76NM1

PDB ID(s): None

Isoelectric Point: 9.47

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000133 ER lumen protein retaining receptor
PFam PF00810 ER lumen protein retaining receptor
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
8223485 Identification and localization of ERD2 in the malaria parasite Plasmodiumfalciparum: separation from sites of sphingomyelin synthesis and implications fororganization of the Golgi. Elmendorf HG, Haldar K 10.1002/j.1460-2075.1993.tb06165.x
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
21075148 Evidence for prenylation-dependent targeting of a Ykt6 SNARE in Plasmodiumfalciparum. Ayong L, DaSilva T, ..., Chakrabarti D 10.1016/j.molbiopara.2010.11.007
29038295 Characterization of aromatic residue-controlled protein retention in theendoplasmic reticulum of Saccharomyces cerevisiae Mei M, Zhai C, ..., Yi L 10.1074/jbc.M117.812107
33604307 Rab5b-Associated Arf1 GTPase Regulates Export of N-Myristoylated Adenylate Kinase2 From the Endoplasmic Reticulum in Plasmodium falciparum Taku I, Hirai T, ..., Saito-Nakano Y 10.3389/fcimb.2020.610200