Genome location: Pf3D7_13_v3:2,145,221..2,147,873(-)
Genome classification: Core
Product Description: ER lumen protein retaining receptor
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005794 | Golgi apparatus |
Component | GO:0005801 | cis-Golgi network |
Component | GO:0005783 | endoplasmic reticulum |
Function | GO:0046923 | ER retention sequence binding |
Function | GO:0005046 | KDEL sequence binding |
Function | GO:0038023 | signaling receptor activity |
Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
Process | GO:0006621 | protein retention in ER lumen |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.08 | 0.96 |
Trophozoite | expressed | 0.19 | 0.87 |
Schizont | expressed | 0.24 | 0.83 |
Gametocyte | expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1353600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.137 | MFS: -2.972 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1130200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q76NM1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101087
Most Similar Human Ortholog: O43731
TM-align score: 0.97 | RMSD: 1.03
Seq Identity: 0.45 | Length: 214 / 221
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000100196 | KDEL endoplasmic reticulum protein retention receptor 3 |
ENSG00000136240 | KDEL endoplasmic reticulum protein retention receptor 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 165
Non-coding: 153 | Synonymous: 12 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 221 | Molecular Weight (kDa): 26.447
PDB ID(s): None
Isoelectric Point: 9.47
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000133 | ER lumen protein retaining receptor |
PFam | PF00810 | ER lumen protein retaining receptor |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
8223485 | Identification and localization of ERD2 in the malaria parasite Plasmodiumfalciparum: separation from sites of sphingomyelin synthesis and implications fororganization of the Golgi. | Elmendorf HG, Haldar K | 10.1002/j.1460-2075.1993.tb06165.x |
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
21075148 | Evidence for prenylation-dependent targeting of a Ykt6 SNARE in Plasmodiumfalciparum. | Ayong L, DaSilva T, ..., Chakrabarti D | 10.1016/j.molbiopara.2010.11.007 |
29038295 | Characterization of aromatic residue-controlled protein retention in theendoplasmic reticulum of Saccharomyces cerevisiae | Mei M, Zhai C, ..., Yi L | 10.1074/jbc.M117.812107 |
33604307 | Rab5b-Associated Arf1 GTPase Regulates Export of N-Myristoylated Adenylate Kinase2 From the Endoplasmic Reticulum in Plasmodium falciparum | Taku I, Hirai T, ..., Saito-Nakano Y | 10.3389/fcimb.2020.610200 |