Genome location: Pf3D7_13_v3:2,149,723..2,150,864(+)
Genome classification: Core
Product Description: reactive oxygen species modulator 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005744 | TIM23 mitochondrial import inner membrane translocase complex |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0030150 | protein import into mitochondrial matrix |
| Process | GO:0045039 | protein insertion into mitochondrial inner membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 0.99 |
| Trophozoite | possibly expressed | 0.03 | 0.98 |
| Schizont | possibly expressed | 0.00 | 1.00 |
| Gametocyte | possibly expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1353700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.132 | MFS: -3.072 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDG4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 4 | 4 | 10 |
| disruptive | 0 | 6 | 12 | 18 |
| missense | 0 | 6 | 12 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 12 | 4 | 13 |
| disruptive | 4 | 33 | 19 | 44 |
| missense | 1 | 25 | 17 | 32 |
PlasmoDB Total SNPs: 99
Non-coding: 99 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 168 | Molecular Weight (kDa): 19.026
UniProt ID(s): Q8IDG4
PDB ID(s): None
Isoelectric Point: 9.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR018450 | Romo1/Mgr2 |
| PFam | PF10247 | Romo1/Mgr2 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |