PF3D7_1354000

Genome location: Pf3D7_13_v3:2,155,755..2,157,542(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.02	0.99
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.41	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1354000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.629 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDG1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533495

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	36	20	34
disruptive	20	117	61	143
missense	18	116	60	130

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	75	33	37
disruptive	39	240	84	178
missense	33	216	74	143

PlasmoDB Total SNPs: 58

Non-coding: 0 | Synonymous: 37 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 595 | Molecular Weight (kDa): 71.975

UniProt ID(s): Q8IDG1

PDB ID(s): None

Isoelectric Point: 10.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A