PF3D7_1354100

Genome location: Pf3D7_13_v3:2,157,908..2,159,670(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	0.99
Trophozoite	no data	0.02	0.99
Schizont	no data	0.01	1.00
Gametocyte	no data	0.03	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1354100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.927 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDG0

"Best" AlphaFill ligand hit: 1PG (2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol, Local RMSD=1.74) with 5FRE (Global RMSD=23.17)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533644

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	22	9	22
disruptive	5	52	33	74
missense	3	49	32	73

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	38	10	37
disruptive	11	130	52	106
missense	8	118	44	69

PlasmoDB Total SNPs: 66

Non-coding: 40 | Synonymous: 17 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 356 | Molecular Weight (kDa): 43.095

UniProt ID(s): Q8IDG0

PDB ID(s): None

Isoelectric Point: 6.83

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A