PF3D7_1354400

Genome location: Pf3D7_13_v3:2,169,202..2,172,008(-)

Genome classification: Core

Function and Localization

Product Description: V-type proton ATPase 21 kDa proteolipid subunit, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: 3.6.3.14 (Transferred entry: 7.1.2.2)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016021	integral component of membrane
Component	GO:0016471	vacuolar proton-transporting V-type ATPase complex
Function	GO:0046961	proton-transporting ATPase activity, rotational mechanism

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.03	0.98
Trophozoite	expressed	0.07	0.95
Schizont	expressed	0.06	0.95
Gametocyte	expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1354400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.251 | MFS: -2.73 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1131000)

Relative Growth Rate: 0.10 ± nan
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDF7

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.6.3.14	H+-transporting two-sector ATPase	No BRENDA inhibitors

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102000

Most Similar Human Ortholog: Q99437

TM-align score: 0.90 | RMSD: 1.63

Seq Identity: 0.43 | Length: 172 / 181

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000117410	ATPase H+ transporting V0 subunit b

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 101

Non-coding: 94 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 181 | Molecular Weight (kDa): 19.124

UniProt ID(s): Q8IDF7

PDB ID(s): None

Isoelectric Point: 7.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000245	V-ATPase proteolipid subunit
InterPro	IPR002379	V-ATPase proteolipid subunit C-like domain
InterPro	IPR035921	F/V-ATP synthase subunit C superfamily
PFam	PF00137	V-ATPase proteolipid subunit C-like domain
Superfamily	SSF81333	F/V-ATP synthase subunit C superfamily