PF3D7_1354600

Genome location: Pf3D7_13_v3:2,175,867..2,177,361(-)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal protein L7, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0022625	cytosolic large ribosomal subunit
Function	GO:0003723	RNA binding
Function	GO:0003735	structural constituent of ribosome
Process	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.63	0.70
Trophozoite	not expressed	0.36	0.80
Schizont	not expressed	0.07	0.96
Gametocyte	not expressed	0.33	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1354600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -2.982 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5I4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130041

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	11	9	15
disruptive	5	27	9	53
missense	5	27	9	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	25	11	13
disruptive	11	58	34	57
missense	8	48	31	48

PlasmoDB Total SNPs: 26

Non-coding: 13 | Synonymous: 8 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 252 | Molecular Weight (kDa): 31.048

UniProt ID(s): C0H5I4

PDB ID(s): None

Isoelectric Point: 10.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036919	Ribosomal protein L30, ferredoxin-like fold domain superfamily
InterPro	IPR039699	Ribosomal protein L7/L30
PFam	N/A	N/A
Superfamily	SSF55129	Ribosomal protein L30, ferredoxin-like fold domain superfamily