PF3D7_1354900

Genome location: Pf3D7_13_v3:2,183,640..2,186,476(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.21	0.89
Trophozoite	expressed	0.45	0.74
Schizont	expressed	0.25	0.83
Gametocyte	not expressed	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1354900

Resistome Missense Mutations: N370I

Resistome Compounds with Missense Mutations: MMV028038

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.135 | MFS: -2.816 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDF2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533372

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	34	19	46
disruptive	24	97	55	144
missense	19	82	51	126

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	73	30	46
disruptive	47	231	92	189
missense	31	192	71	139

PlasmoDB Total SNPs: 101

Non-coding: 44 | Synonymous: 28 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 637 | Molecular Weight (kDa): 76.565

UniProt ID(s): Q8IDF2

PDB ID(s): None

Isoelectric Point: 5.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A