PF3D7_1355200

Genome location: Pf3D7_13_v3:2,190,835..2,194,498(-)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.37	0.82
Trophozoite	not expressed	0.18	0.90
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1355200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.192 | MFS: -3.327 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K936

"Best" AlphaFill ligand hit: UPG (uridine-5'-diphosphate-glucose, Local RMSD=3.70) with 2VKD (Global RMSD=27.78)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533081

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	48	30	81
disruptive	25	140	83	159
missense	24	138	81	144

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	97	50	67
disruptive	49	255	119	225
missense	43	229	110	185

PlasmoDB Total SNPs: 91

Non-coding: 26 | Synonymous: 26 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 1017 | Molecular Weight (kDa): 121.355

UniProt ID(s): A0A5K1K936

PDB ID(s): None

Isoelectric Point: 9.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	PF08373	RAP domain
Superfamily	N/A	N/A