PF3D7_1355600 (PIP1)

Genome location: Pf3D7_13_v3:2,202,011..2,205,513(-)

Genome classification: Core

Function and Localization

Product Description: PhIL1 interacting protein PIP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0070258	inner membrane pellicle complex
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	not expressed	0.09	0.95
Schizont	not expressed	0.02	0.99
Gametocyte	possibly expressed	0.44	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1355600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.05 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDE6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532740

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	39	26	43
disruptive	23	79	32	92
missense	22	78	31	86

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	77	32	43
disruptive	44	144	62	130
missense	41	133	52	106

PlasmoDB Total SNPs: 164

Non-coding: 111 | Synonymous: 28 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 562 | Molecular Weight (kDa): 66.219

UniProt ID(s): Q8IDE6

PDB ID(s): None

Isoelectric Point: 10.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A