PF3D7_1355800 (SF3B5)

Genome location: Pf3D7_13_v3:2,212,459..2,215,136(+)

Genome classification: Core

Function and Localization

Product Description: splicing factor 3B subunit 5, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005686	U2 snRNP
Component	GO:0005634	nucleus
Component	GO:0071011	precatalytic spliceosome
Process	GO:0000398	mRNA splicing, via spliceosome
Process	GO:0000245	spliceosomal complex assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.13	0.93
Trophozoite	no data	0.12	0.92
Schizont	no data	0.04	0.97
Gametocyte	no data	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1355800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.847 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5I5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103168

Most Similar Human Ortholog: Q9BWJ5

TM-align score: 0.71 | RMSD: 2.37

Seq Identity: 0.49 | Length: 78 / 86

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000169976	splicing factor 3b subunit 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	1	5	7
disruptive	2	2	4	9
missense	0	2	4	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	11	3	5
disruptive	3	10	9	30
missense	0	10	9	24

PlasmoDB Total SNPs: 125

Non-coding: 116 | Synonymous: 9 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 86 | Molecular Weight (kDa): 10.11

UniProt ID(s): C0H5I5

PDB ID(s): None

Isoelectric Point: 10.27

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009846	Splicing factor 3B subunit 5/RDS3 complex subunit 10
InterPro	IPR017089	Splicing factor 3B, subunit 5
PFam	PF07189	Splicing factor 3B subunit 5/RDS3 complex subunit 10
Superfamily	N/A	N/A