PF3D7_1356000

Genome location: Pf3D7_13_v3:2,218,743..2,222,939(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	not expressed	0.12	0.93
Schizont	not expressed	0.09	0.94
Gametocyte	expressed	1.05	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1356000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.727 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1132300)

Modification: Disrupted | RMgm-3099

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDE2

"Best" AlphaFill ligand hit: NUP (, Local RMSD=0.73) with 2Q8Z (Global RMSD=24.25)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533288

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	19	75	48	120
disruptive	36	239	144	326
missense	35	224	136	307

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	173	80	121
disruptive	81	541	220	398
missense	62	490	204	327

PlasmoDB Total SNPs: 114

Non-coding: 0 | Synonymous: 65 | Nonsynonymous: 49 | Stop Codon: 0

Protein Information

Protein Length: 1398 | Molecular Weight (kDa): 166.279

UniProt ID(s): Q8IDE2

PDB ID(s): None

Isoelectric Point: 9.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A