PF3D7_1356100

Genome location: Pf3D7_13_v3:2,223,411..2,227,718(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.96
Trophozoite	possibly expressed	0.83	0.58
Schizont	expressed	1.43	0.38
Gametocyte	expressed	1.39	0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1356100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.274 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1132400)

Relative Growth Rate: 1.07 ± 0.15
Confidence: 5.24

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1132400)

Modification: Disrupted | RMgm-3100

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDE1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533273

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	75	29	78
disruptive	51	166	107	218
missense	26	124	80	169

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	127	45	83
disruptive	96	374	162	302
missense	46	268	125	211

PlasmoDB Total SNPs: 226

Non-coding: 114 | Synonymous: 72 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 964 | Molecular Weight (kDa): 113.756

UniProt ID(s): Q8IDE1

PDB ID(s): None

Isoelectric Point: 5.48

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A