Genome location: Pf3D7_13_v3:2,228,269..2,229,941(-)
Genome classification: Core
Product Description: mitochondrial import inner membrane translocase subunit TIM23, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005744 | TIM23 mitochondrial import inner membrane translocase complex |
| Component | GO:0031305 | integral component of mitochondrial inner membrane |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0030943 | mitochondrion targeting sequence binding |
| Function | GO:0008320 | protein transmembrane transporter activity |
| Process | GO:0030150 | protein import into mitochondrial matrix |
| Process | GO:0006626 | protein targeting to mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.09 | 0.95 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1356200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.226 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDE0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P32897 | Mitochondrial import inner membrane translocase subunit TIM23 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | OrthoMCL | MLS000029341med.21724, Compound 153MLS000038396MLS000041934... |
Ortholog Group (OrthoMCL): OG6_102649
Most Similar Human Ortholog: O14925
TM-align score: 0.62 | RMSD: 3.20
Seq Identity: 0.19 | Length: 129 / 167
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000265354 | translocase of inner mitochondrial membrane 23 |
Protein Length: 167 | Molecular Weight (kDa): 18.171
UniProt ID(s): Q8IDE0
PDB ID(s): None
Isoelectric Point: 9.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | PF02466 | N/A |
| Superfamily | N/A | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 42
Non-coding: 39 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 27458014 | The Import of Proteins into the Mitochondrion of Toxoplasma gondii. | van Dooren GG, Yeoh LM, Striepen B, McFadden GI | 10.1074/jbc.M116.725069 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 37696957 | Molecular pathway of mitochondrial preprotein import through the TOM-TIM23supercomplex | Zhou X, Yang Y, ..., Li L | 10.1038/s41594-023-01103-7 |
| 38416681 | Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress | Eldeeb MA, Bayne AN, ..., Fon EA | 10.1073/pnas.2313540121 |
| 37344598 | Structural basis of mitochondrial protein import by the TIM23 complex | Sim SI, Chen Y, ..., Park E | 10.1038/s41586-023-06239-6 |
| 38360717 | The architecture of substrate-engaged TOM-TIM23 supercomplex reveals preprotein proximity sites for mitochondrial protein translocation | Wang Q, Zhuang J, ..., Yin P | 10.1038/s41421-023-00643-y |
| 37527780 | Central role of Tim17 in mitochondrial presequence protein translocation | Fielden LF, Busch JD, ..., Wiedemann N | 10.1038/s41586-023-06477-8 |
| 37759433 | Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis andMitochondrial Arrangement during Spermiogenesis | Luo ZY, Jiang TX, ..., Qiu XB | 10.3390/cells12182211 |
| 37160114 | TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediateddegradation in damaged mitochondria | Akabane S, Watanabe K, ..., Oka T | 10.1016/j.celrep.2023.112454 |