Product Description: ubiquitin-conjugating enzyme E2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.2.23 (E2 ubiquitin-conjugating enzyme)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Function | GO:0004842 | ubiquitin-protein transferase activity |
| Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Process | GO:0000209 | protein polyubiquitination |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.21 | 0.87 |
| Schizont | expressed | 0.75 | 0.58 |
| Gametocyte | expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1356300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -2.666 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IDD9
"Best" AlphaFill ligand hit: BU3 ((r,r)-2,3-butanediol, Local RMSD=0.02) with 1Z2U (Global RMSD=1.21)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.2.23 | E2 ubiquitin-conjugating enzyme | CC0651[1,1'-biphenyl]-2-ol[1,1'-biphenyl]-2,2'-diol4-phenyl-1,3-thiazol-2-amine[1,1'-biphenyl]-2-sulfonamide5-chloro-1,3-benzoxazole-2-thiol6-chloro-1,3-benzoxazole-2-thiol1-(1,3-benzothiazol-2-yl)methanamine2-amino-5-phenylfuran-3-carbonitrile3-(2-hydroxyphenyl)pyridin-2(1H)-one3-methyl-3,4-dihydroquinazolin-2(1H)-one5,6-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103192
Most Similar Human Ortholog: P61086
TM-align score: 0.74 | RMSD: 1.06
Seq Identity: 0.50 | Length: 152 / 202
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000078140 | ubiquitin conjugating enzyme E2 K |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 13 | 7 | 18 |
| disruptive | 0 | 2 | 3 | 6 |
| missense | 0 | 2 | 3 | 4 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 23 | 10 | 11 |
| disruptive | 0 | 9 | 12 | 47 |
| missense | 0 | 5 | 8 | 36 |
PlasmoDB Total SNPs: 125
Non-coding: 121 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 202 | Molecular Weight (kDa): 22.883
UniProt ID(s): Q8IDD9
PDB ID(s): None
Isoelectric Point: 5.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000608 | Ubiquitin-conjugating enzyme E2 |
| InterPro | IPR009060 | UBA-like superfamily |
| InterPro | IPR015940 | Ubiquitin-associated domain |
| InterPro | IPR016135 | Ubiquitin-conjugating enzyme/RWD-like |
| InterPro | IPR023313 | Ubiquitin-conjugating enzyme, active site |
| PFam | PF00179 | Ubiquitin-conjugating enzyme E2 |
| PFam | PF00627 | Ubiquitin-associated domain |
| Superfamily | SSF46934 | UBA-like superfamily |
| Superfamily | SSF54495 | Ubiquitin-conjugating enzyme/RWD-like |
No associated publications