PF3D7_1356500

Genome location: Pf3D7_13_v3:2,239,261..2,240,004(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	nd	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	possibly expressed	0.00	1.00
Gametocyte	expressed	0.02	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1356500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.189 | MFS: -2.677 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1132800)

Relative Growth Rate: 1.00 ± 0.09
Confidence: 6.16

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1132800)

Modification: Disrupted | RMgm-3102

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDD7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122568

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	5	19
disruptive	6	18	4	20
missense	6	18	4	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	24	10	24
disruptive	11	39	16	42
missense	10	30	12	31

PlasmoDB Total SNPs: 39

Non-coding: 28 | Synonymous: 5 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 195 | Molecular Weight (kDa): 22.842

UniProt ID(s): Q8IDD7

PDB ID(s): None

Isoelectric Point: 7.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A