PF3D7_1356600

Genome location: Pf3D7_13_v3:2,240,792..2,243,672(-)

Genome classification: Core

Function and Localization

Product Description: regulator of chromosome condensation, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.09	0.95
Trophozoite	possibly expressed	0.15	0.90
Schizont	expressed	0.27	0.82
Gametocyte	possibly expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1356600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.242 | MFS: -2.782 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDD6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_124292

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	35	22	42
disruptive	1	12	8	26
missense	1	12	8	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	72	27	38
disruptive	5	35	27	90
missense	2	27	24	59

PlasmoDB Total SNPs: 56

Non-coding: 42 | Synonymous: 13 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 480 | Molecular Weight (kDa): 54.595

UniProt ID(s): Q8IDD6

PDB ID(s): None

Isoelectric Point: 8.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000408	Regulator of chromosome condensation, RCC1
InterPro	IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFam	PF00415	Regulator of chromosome condensation, RCC1
PFam	PF13540
Superfamily	SSF50985	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II