Genome location: Pf3D7_13_v3:2,248,107..2,262,674(+)
Genome classification: Core
Product Description: aurora-related kinase ARK3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Component | GO:0005813 | centrosome |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:0000922 | spindle pole |
| Function | GO:0005515 | protein binding |
| Function | GO:0004674 | protein serine/threonine kinase activity |
| Process | GO:0000278 | mitotic cell cycle |
| Process | GO:0006468 | protein phosphorylation |
| Process | GO:0032465 | regulation of cytokinesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.17 | 0.92 |
| Trophozoite | not expressed | 0.30 | 0.85 |
| Schizont | expressed | 2.28 | 0.34 |
| Gametocyte | expressed | 1.30 | 0.42 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1356800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.684 | #Insertions: 6
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 36 | 218 | 124 | 258 |
| disruptive | 136 | 717 | 362 | 924 |
| missense | 107 | 671 | 344 | 834 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 82 | 406 | 193 | 278 |
| disruptive | 282 | 1458 | 569 | 1274 |
| missense | 207 | 1299 | 506 | 947 |
PlasmoDB Total SNPs: 597
Non-coding: 156 | Synonymous: 204 | Nonsynonymous: 237 | Stop Codon: 0
Protein Length: 4044 | Molecular Weight (kDa): 475.716
UniProt ID(s): Q8IDD4
PDB ID(s): None
Isoelectric Point: 9.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000719 | Protein kinase domain |
| InterPro | IPR008271 | Serine/threonine-protein kinase, active site |
| InterPro | IPR011009 | Protein kinase-like domain superfamily |
| InterPro | IPR017441 | Protein kinase, ATP binding site |
| PFam | PF00069 | Protein kinase domain |
| Superfamily | SSF56112 | Protein kinase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 26791088 | Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues. | Vieira WA, Coetzer TL | 10.1186/s12936-015-1065-9 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 26833682 | The conserved apicomplexan Aurora kinase TgArk3 is involved in endodyogeny,duplication rate and parasite virulence | Berry L, Chen CT, ..., Daher W | 10.1111/cmi.12571 |