Product Description: elongation factor 1-alpha
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005853 | eukaryotic translation elongation factor 1 complex |
| Component | GO:0020030 | infected host cell surface knob |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0003746 | translation elongation factor activity |
| Process | GO:0006412 | translation |
| Process | GO:0006414 | translational elongation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.77 | 0.66 |
| Trophozoite | expressed | 1.21 | 0.43 |
| Schizont | expressed | 0.21 | 0.86 |
| Gametocyte | expressed | 0.32 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1357000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.184 | MFS: -2.892 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1133400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1133300)
Modification: Disrupted | RMgm-174
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100227
Most Similar Human Ortholog: P68104
TM-align score: 0.99 | RMSD: 1.16
Seq Identity: 0.71 | Length: 443 / 443
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101210 | eukaryotic translation elongation factor 1 alpha 2 |
| ENSG00000156508 | eukaryotic translation elongation factor 1 alpha 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 106
Non-coding: 73 | Synonymous: 23 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 443 | Molecular Weight (kDa): 48.959
UniProt ID(s): Q8I0P6
PDB ID(s): None
Isoelectric Point: 9.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000795 | Transcription factor, GTP-binding domain |
| InterPro | IPR004160 | Translation elongation factor EFTu/EF1A, C-terminal |
| InterPro | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| InterPro | IPR004539 | Translation elongation factor EF1A, eukaryotic/archaeal |
| InterPro | IPR009000 | Translation protein, beta-barrel domain superfamily |
| InterPro | IPR009001 | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR031157 | Tr-type G domain, conserved site |
| PFam | PF00009 | Transcription factor, GTP-binding domain |
| PFam | PF03143 | Translation elongation factor EFTu/EF1A, C-terminal |
| PFam | PF03144 | Translation elongation factor EFTu-like, domain 2 |
| Superfamily | SSF50447 | Translation protein, beta-barrel domain superfamily |
| Superfamily | SSF50465 | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 28981210 | Proteome and Structural Organization of the Knob Complex on the Surface of thePlasmodium Infected Red Blood Cell. | Alampalli SV, Grover M, ..., Acharya P | 10.1002/prca.201600177 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |