Product Description: elongation factor 1-alpha
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005853 | eukaryotic translation elongation factor 1 complex |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003746 | translation elongation factor activity |
| Process | GO:0006412 | translation |
| Process | GO:0006414 | translational elongation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.20 | 0.90 |
| Trophozoite | expressed | 0.31 | 0.81 |
| Schizont | expressed | 0.06 | 0.95 |
| Gametocyte | expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1357100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.184 | MFS: -2.772 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1133400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1133400)
Modification: Disrupted | RMgm-3104
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I0P6
"Best" AlphaFill ligand hit: 7PG (2,5,8,11,14,17,20,23-octaoxapentacosan-25-ol, Local RMSD=0.17) with 4RJL (Global RMSD=7.50)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P05453 | Eukaryotic peptide chain release factor GTP-binding subunit | OrthoDB | TERAIODOPHENOLPHATHALIN |
Ortholog Group (OrthoMCL): OG6_100227
Most Similar Human Ortholog: P68104
TM-align score: 0.99 | RMSD: 1.16
Seq Identity: 0.71 | Length: 443 / 443
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101210 | eukaryotic translation elongation factor 1 alpha 2 |
| ENSG00000156508 | eukaryotic translation elongation factor 1 alpha 1 |
Protein Length: 443 | Molecular Weight (kDa): 48.959
UniProt ID(s): A0A2P1JI60, Q8I0P6
PDB ID(s): None
Isoelectric Point: 9.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000795 | Transcription factor, GTP-binding domain |
| InterPro | IPR004160 | Translation elongation factor EFTu/EF1A, C-terminal |
| InterPro | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| InterPro | IPR004539 | Translation elongation factor EF1A, eukaryotic/archaeal |
| InterPro | IPR009000 | Translation protein, beta-barrel domain superfamily |
| InterPro | IPR009001 | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR031157 | Tr-type G domain, conserved site |
| PFam | PF00009 | Transcription factor, GTP-binding domain |
| PFam | PF03143 | Translation elongation factor EFTu/EF1A, C-terminal |
| PFam | PF03144 | Translation elongation factor EFTu-like, domain 2 |
| Superfamily | SSF50447 | Translation protein, beta-barrel domain superfamily |
| Superfamily | SSF50465 | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 9 | 8 | 7 |
| disruptive | 1 | 0 | 0 | 7 |
| missense | 1 | 0 | 0 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 19 | 5 | 1 |
| disruptive | 1 | 2 | 1 | 9 |
| missense | 1 | 0 | 0 | 5 |
PlasmoDB Total SNPs: 53
Non-coding: 27 | Synonymous: 25 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |