PF3D7_1357300

Genome location: Pf3D7_13_v3:2,274,713..2,275,078(+)

Genome classification: Core

Function and Localization

Product Description: dynein light chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030286	dynein complex
Component	GO:0005875	microtubule associated complex
Function	GO:0045505	dynein intermediate chain binding
Function	GO:0051959	dynein light intermediate chain binding
Function	GO:0003777	microtubule motor activity
Process	GO:0007017	microtubule-based process
Process	GO:2000582	obsolete positive regulation of microtubule motor activity, plus-end-directed

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.01	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1357300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.121 | MFS: -2.981 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IDD2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149564

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	5	3	7
disruptive	2	9	6	15
missense	2	8	6	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	10	3	10
disruptive	2	22	18	30
missense	2	18	15	19

PlasmoDB Total SNPs: 8

Non-coding: 0 | Synonymous: 4 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 121 | Molecular Weight (kDa): 14.14

UniProt ID(s): Q8IDD2

PDB ID(s): None

Isoelectric Point: 7.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001372	Dynein light chain, type 1/2
InterPro	IPR037177	Dynein light chain superfamily
PFam	PF01221	Dynein light chain, type 1/2
Superfamily	SSF54648	Dynein light chain superfamily