PF3D7_1357400

Genome location: Pf3D7_13_v3:2,275,621..2,280,940(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	not expressed	0.49	0.72
Schizont	not expressed	0.44	0.73
Gametocyte	not expressed	0.64	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1357400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.684 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8N6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533610

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	61	32	87
disruptive	46	213	107	262
missense	30	172	87	215

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	117	54	88
disruptive	109	413	138	333
missense	56	338	113	215

PlasmoDB Total SNPs: 173

Non-coding: 43 | Synonymous: 71 | Nonsynonymous: 59 | Stop Codon: 0

Protein Information

Protein Length: 1179 | Molecular Weight (kDa): 141.027

UniProt ID(s): A0A5K1K8N6

PDB ID(s): None

Isoelectric Point: 5.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A